David Shankbone · CC BY 3.0

Camryn Manheim first drew attention with her off-Broadway one-woman show Wake Up, I'm Fat, a frank account of her own body that set the tone for a career refusing to shrink herself for the industry. She won both a Golden Globe and a Primetime Emmy for playing attorney Ellenor Frutt on The Practice, and went on to lead roles on Ghost Whisperer, Person of Interest, and Law & Order.