Super Festivals from Ft. Lauderdale, USA · CC BY 2.0

Spent seven seasons as newlywed Jamie Buchman on Mad About You, winning four Primetime Emmys and three Golden Globes for the role, before crossing into film as a leading lady with Twister and Cast Away. She won the Academy Award for Best Actress playing a waitress and single mother opposite Jack Nicholson in As Good as It Gets. She later moved into directing, and earned a Best Supporting Actress nomination playing a sex surrogate opposite John Hawkes in The Sessions.