iDominick · CC BY-SA 2.0

Lizzy Caplan broke through playing the sharp-tongued Janis Ian in Mean Girls, then built a career on roles that resist easy likability — most notably as sex researcher Virginia Johnson in Masters of Sex and as Libby Epstein in Fleishman Is in Trouble, both of which earned her Emmy nominations. She has moved fluidly between television and film since her start on the cult series Freaks and Geeks.