Hazzzzzzi · CC BY-SA 4.0

Nan Goldin redefined documentary photography with an intimate, unguarded style, turning her own life and "chosen family" into her subject in The Ballad of Sexual Dependency, a slideshow and monograph that chronicled bohemian and LGBT communities through the HIV/AIDS crisis of the 1980s. She later founded the advocacy group P.A.I.N. (Prescription Addiction Intervention Now), campaigning against the opioid epidemic.