Xuthoria · CC BY-SA 4.0

Simon Helberg spent twelve seasons playing Howard Wolowitz on The Big Bang Theory, a role that won him a Critics' Choice Award, before taking on real-life accompanist Cosmé McMoon opposite Meryl Streep in Florence Foster Jenkins (2016), a performance that earned him a Golden Globe nomination. He came up through MADtv's cast in the early 2000s and has built a film career in between, appearing in Good Night, and Good Luck, A Serious Man and Annette.